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KMID : 0366919890010010037
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Sungkyun Pharmceutical Journal
1989 Volume.1 No. 1 p.37 ~ p.42
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Methylated Basic Amino Acids in Serum of the Experimentally Induced Hyper- and Hypothyroid Rats
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Choi Whan-Soo
Hong Seong-Ryeul
Lee Hyang-Woo
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Abstract
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Abstract-Free methylated basic amino acids in serum of rats were derivatized with PITC reagents and were separated by reverse-phase HPLC. Quantitation was achieved by post column UV absorbance at 254 nm. The method was applied to the quantitation analysis of MMA and TML level in serum of hypo-, hyperthyroid and normal rats.
The concentration of MMA, DMA and TML in serum of normal rats were 3.85, 4.84 and 1.53 μM, respectively. In the case of hyperthyroid rats, each concentration was increase about 2-4 times than that of normal rats. Whereas, in the case of hypothyroid rats, each concentration was decreased about 0.44-0.92 times than that of normal rats.
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